medicinal preparations with an inhibitory effect on platelet aggregation and the phosphodiesterase inhibition in these preparations, and to use carbostyrilderivaten.

摘要

Novel carbostyril derivatives having platelet aggregation inhibitory action, antiinflamatory action, antiulcer action, vasodilatory action and phosphodiesterase inhibitory action and are useful for preventing or curing thrombus, arteriosclerosis, hypertension, asthma and other like diseases, and also useful as an antiinflamatory or anti-ulcer agent, represented by the formula IMAGE wherein R1 is hydrogen, C1-4 alkyl, C2-4 alkenyl, phenyl-C1-4 alkyl-; R2 is hydrogen, a halogen atom, hydroxy, phenyl-C1-4 alkoxy; R3 is hydrogen, hydroxy, C1-4 alkyl; R4 is C3-8 cycloalkyl, substituted or unsubstituted phenyl, C3-8 cycloalkyl-C1-4 alkyl, 2-(3,4-dimethoxyphenyl)-ethyl, R5 is hydrogen, C1-8 alkyl, C2-4 alkenyl, phenyl, C3-8 cycloalkyl, phenyl-C1-4 alkyl, C3-8 cycloalkyl-C1-4 alkyl, m is an integer of 1 - 3, l and n which may be same or different, and are respectively 0 or an integer of 1 - 7 and the sum of l and n is not exceeding 7, the carbon-carbon bond at 3- and 4-positions in the carbostyril skelton is either single or double bond.