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Prepn. of anti-leukaemic behenic arabino furanosyl cytosine - from cytarabine and behenic acid, catalysed by silicon tetra:chloride, is anticancer agent
Prepn. of anti-leukaemic behenic arabino furanosyl cytosine - from cytarabine and behenic acid, catalysed by silicon tetra:chloride, is anticancer agent
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机译:准备四氯化硅催化从阿糖胞苷和山hen酸中提取抗白血病的山药阿拉伯糖呋喃糖基胞嘧啶是抗癌剂
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摘要
cytosine (I) is prepd. by treating 1-beta-D -arabinofuranosyl cytosine (II) with behenic acid CH3(CH2)20COOH (III) in the presence of a catalytic amount of SiCl4. Specifically (III) is suspended in pyridine and SiCl4 added in a non-polar solvent to give a homogeneous soln. The soln. is treated with (II) and stirred for 2-3 hours at 20-60 deg. C. Addition of cold water gives crystals of (I).
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