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10-BROMOSANDWICINE AND 10-BROMOISOSANDWICINE, AS WELL AS THEIR ADDITIONS SALTS WITH PHARMACOLICAL ACCEPTABLE ACIDS PROCESS FOR THEIR PREPARATION AND THEIR USE
10-BROMOSANDWICINE AND 10-BROMOISOSANDWICINE, AS WELL AS THEIR ADDITIONS SALTS WITH PHARMACOLICAL ACCEPTABLE ACIDS PROCESS FOR THEIR PREPARATION AND THEIR USE
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机译:10-溴山梨花药和10-溴异山梨花药以及它们与药物可接受的酸的盐进行制备和使用的过程
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摘要
10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated Nb-quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.
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