PARTICLES HAVING IMMUNOGENIC PROPERTIES OF ANTIGEN HBS AND CARRYING AN ANTIGENIC SITE FOREIGNING WITH THE ANTIGEN-HBS VECTORS AND AN9MAL5S CELLS POU9-3- amp; 7RO4D3C9ON OF SUCH PARTICLES AND COMPOSITIONS CONTAINING SUCH PARTICLES FOR THE PRODUCTION OF MIXED VACCINES

摘要

The invention relates to particles possessing the essential features of particles based on HBs antigen, these particles being formed from a major polypeptide characteristic of the HBs antigen into which has been incorporated a foreign polypeptide sequence provided with an immunogenic site different from those normally borne by the S gene. The invention also relates to recombinant DNAs coding for the major polypeptide transformed in the manner described above, and to cell lines transformed by this recombinant DNA and capable, in particular when the foreign amino acid sequence contains not more than 16 amino acids, of being excreted into the culture medium of the abovementioned cell line.