intermediate products to anvendning at still for framstellning of 2 - amino -, 9 - (2 - hydroxietoximetyl) adenine and 9 - (2 - hydroxietoximetyl) guanine

摘要

9-(2-Hydroxyethoxymethyl) derivatives of 2-amino-adenine and guanine of formula I are prepared by hydrolysis from compounds of formula II. The reaction is carried out in the presence of a base. The symbols in formula I and II have the meanings given in Patent Claim 1. The novel compounds of formula II are prepared by reacting the guanine or 2-aminoadenine, wherein the 2- and 9-positions, or the 2-, 6- and 9-positions, are acylated, with a diester of 2-oxa-1,4-butanediol. This reaction is carried out in the presence of a catalytic amount of an acid. The 9-(2-hydroxyethoxymethyl) derivatives of 2-aminoadenine and guanine are novel and exhibit an antiviral action, especially against the classes of the DNA- and RNA-viruses. IMAGE