A process for the optical resolution of mixtures Race- micas alpha-naphthyl propionic acids

摘要

A new process for the optical resolution of racemic mixtures of alpha -naphthyl-propionic acids of formula …CHEM… where R1 is an alkyl group, straight or branched, having from 1 to 6 carbon atoms and R2 represents an hydrogen or an halogen atom. …??This process comprises reacting a racemic mixture of a compound of formula II …CHEM… wherein R1 and R2 have the above seen meanings and R3 is a reactive group, with an optically active compound of formula… R4-NH2      III… wherein R4 is the residue of a primary or secondary alcohol which, taken with the NH2 radical, forms an optically active beta -aminoalcohol, to give a pair of diastereoisomeric amides of