New histamine H-2 antagonist thiadiazine di:oxide cpds.

摘要

Thiadiazine dioxide cpds. of the formula (I) and their salts are new. Tantomeric forms are also included. R1 and R2 each=H, 1-6C alkyl, aryl-(1-6C alkyl), heteroaryl-(1-6C alkyl), 3-10C cycloalkyl, 2-6C hydroxyalkyl or 2-6C haloalkyl, no halogen or OH substituent being on a C atom adjacent to N; or R1 and R2 together are -(CH2)q- in which q is 4-7; n=1-6; Z=1,3-phenylene, 1,4-phenylene or 2-4 pyridyl (the aminoalkyl gp. being in the 4-position; m=zero or 1; Y=O, S or CH2; p=2-4; R3 and R4 each=H, 1-6C alkyl, aryl, aryl-(1-6C alkyl) or pyridyl-(1-6C alkyl) or R3 and R4 and the adjacent C atom form a benzene ring, opt. substd. by 1-6C alkyl. - Specific cpd. is 3-(3-(3-(piperidinomethyl) phenoxy)propylamino)-5,6- dihydro -1,2,4-thiadiazine-1,1-dioxide.