Method for preparing Derivatives of 1.6 - naftiridina

摘要

Procedure for pteparar 1.6 - naftiridina Derivatives.Comprises: a) reacting a dihydropyridine of formula (iii) with S - triazine, in the presence of alkali metal alcoholates or Beam, between 100 and 150jc or dimethylformamide and dimethylsulfoxide, to produce 1.6 - naftiridinona of formula (ii); and (b) (ii) with rent or dialkyl sulfates Trialquiloxonio salts,In n-pentane dietileter or dimethylformamide and between c20jc and the boiling temperature of the Solvent, to obtain a compound of formula (i) and their salts pharmacologically safe.Being: R1, aromatic Ring or heteroaromatico replaced or not replaced; R2 and R4, linear or branched alkyl C 4 h, alkyl, R3, R5 and R6 and others; and, alcoxicarbonilo carboxyl or linear or branched chain C 17. Used to combat Heart and Brain Vascular Diseases, peripheral (myocardiac ischemia).