COMPOSITIONS OF SPIRO-HYDANTOIN COMPOUNDS FOR INHIBITING ALDOSE REDUCTASE ACTIVITY

摘要

ABSTRACTA pharmaceutical composition comprising:(a) a compound of general formula:wherein X and Y, independently, represent a group selectedfrom H, F, Cl, Br, I, -CH3, -OCH3, -SCH3, -S(O)CH3 and-S(O2)CH3; and Z represents a group selected from H, F,Cl, Br, I, -CH3 and -OCH3; with the proviso: (i) thatwhen X represents H and Z represents H or F, Y representsa group selected from Cl, Br, I, -CH3 and -OCH3; and(ii) when Y represents H and Z represents H or F, Xrepresents a group selected from Cl, Br, I, -CH3 and-OCH3; and (b) a pharmaceutical carrier.