N-SUBSTITUTED AMIDES OR AROMATIC SULFONIC ACIDS AND THEIR USE INA TREATING THROMBOEMBOLIC DISORDERS

摘要

Sulphonylaminoethyl compounds of the formula IMAGE in which R1 denotes a phenyl group which is optionally mono- or disubstituted by a methyl group or a halogen atom, where the substituents can be identical or different, a biphenylyl group which is optionally substituted by a halogen atom, or a naphthyl, pyridyl or thienyl group, R2 denotes a hydrogen atom or a methyl group, A denotes a methylene or methyleneoxy group, where the oxygen atom is linked to the adjacent radical B, B denotes a phenylene or naphthylene group and E denotes a hydroxycarbonyl or alkoxycarbonyl group bonded via a straight-chain or branched alkylene or alkenylene group, where in each case one methylene group of the abovementioned alkylene or alkenylene radicals, which must be linked to the radical B, is replaced by a hydroxymethylene or carbonyl group, or denotes a 4,5-dihydro- pyridazin-3-on-6-yl group which is optionally substituted in the carbon skeleton by 1 or 2 alkyl groups, and their salts with inorganic or organic bases if E contains a hydroxycarbonyl group. The novel compounds have useful pharmacological properties, in particular antithrombotic effects, they are additionally thromboxane antagonists and can be prepared by processes known per se.