and pharmaceutically acceptable salts thereof, whereinR, is hydrogen or methyl;R2 is hydrogen, alkyl, alkanoyl, or arylcarbonyl;R3 and R4 are each aryl; R3 and R4 are each cycloalkyl; R3 is hydrogen or alkyl and R4 is cycloalkyl or 9H-fluoren-9-yl; or R3 is hydrogen or alkyl and R4 is heteroaryl;R5 and R6 are the same or different and each is hydrogen, hydroxy, alkoxy or alkanoyl; andn is 1, 2, 3 and 4."/> Tetrahydronaphthalenols for the treatment of hypertension
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Tetrahydronaphthalenols for the treatment of hypertension

机译:四氢萘老用于治疗高血压

摘要

New compounds, useful for the treatment of hyperten- sion, have the formulaand pharmaceutically acceptable salts thereof, whereinR, is hydrogen or methyl;R2 is hydrogen, alkyl, alkanoyl, or arylcarbonyl;R3 and R4 are each aryl; R3 and R4 are each cycloalkyl; R3 is hydrogen or alkyl and R4 is cycloalkyl or 9H-fluoren-9-yl; or R3 is hydrogen or alkyl and R4 is heteroaryl;R5 and R6 are the same or different and each is hydrogen, hydroxy, alkoxy or alkanoyl; andn is 1, 2, 3 and 4.
机译:用于治疗高血压的新化合物具有以下分子式: <图像文件=“ IMGA0001.GIF” he =“ 25” imgContent =“ chem” imgFormat =“ GIF” inline =“ no” wi =“ 62” /> 和药学其可接受的盐,其中 R,是氢或甲基; R 2 是氢,烷基,烷酰基或芳基羰基; < / ListItem> R 3 和R 4 分别为芳基; R 3 和R 4 分别是环烷基; R 3 是氢或烷基,R 4 是环烷基或9H-芴-9-基;或R 3 是氢或烷基且R 4 是杂芳基; R 5 和R 6 <相同或不同,各自为氢,羟基,烷氧基或烷酰基;并且 n为1、2、3和4。

著录项

  • 公开/公告号EP0163458A1

    专利类型

  • 公开/公告日1985-12-04

    原文格式PDF

  • 申请/专利权人 E.R. SQUIBB & SONS INC.;

    申请/专利号EP19850303472

  • 发明设计人 ATWAL KARNAIL S.;

    申请日1985-05-17

  • 分类号C07C93/14;C07C91/23;C07D209/16;C07D277/64;C07D235/14;C07D263/56;

  • 国家 EP

  • 入库时间 2022-08-22 07:36:21

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