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Novel macrolidic antibiotics having antibiotic activity, process and microorganism for their preparation, and related pharmaceutical compositions
Novel macrolidic antibiotics having antibiotic activity, process and microorganism for their preparation, and related pharmaceutical compositions
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机译:具有抗生素活性,其制备方法和微生物的新型大分子抗生素以及相关药物组合物
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摘要
The fermentation of a substrate selected among erythronolide B, erythronolide A and erythronolide A oxime with a novel mutant, Streptomyces antibioticus ATCC 31771, obtained from an industrial stock for the production of oleandomycin, said novel mutant being incapable of producing the same oleandomycin, permits novel macrolide antibiotics to be produced, having not only an activity range like that of erythromycin, but characterized by a greater stability in acidic environment, whereby for the administration of the antibiotic it is no longer necessary to have recourse to esters and/or salts highly toxic for the organism.
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