RACEMIC ASOCAINOL, METHOD FOR THE PRODUCTION THEREOF, AND THE USE THEREOF IN THE FIGHT AGAINST REITING LINE MALFUNCTIONS

摘要

A process for the preparation of racemic asocainol in the (R,R; S,S)-form and (-)-asocainol in the (S,S)-form as well as the pharmacologically compatible salts thereof is herein described on the basis of a thermal rearrangement of the inactive (R,S)-diastereomer to the (S,S)-form. Racemic (+/-)-asocainol and the (-)-enantiomer are potent antiarrhythmic agents and local anesthetics.