Method of preparation of oligopeptides lysine - tryptophan, their derivatives and their salts with physiologically useful

摘要

The invention relates to a method of preparation of oligopeptides lysine - tryptophan of general formula: & br / (see appended drawing in bopi) & br / according to this process, it is react a compound of formula 2 with a salt of a compound of formula 3 in the presence of an aprotic base and in an inert solvent; & br / (see appended drawing in bopi) & & br / or r and r can be equally b - methylenindole or e - aminobutyl in which the group e - nh is protege, or a residue of a peptide sequence whatsoever (lys) - (try) (c and or d0) is the condition that r or r possesses at least one residue b - methylenindole or e - aminobutyl protege; and r is alkyl, aryl or aralkyl. / p & & p & it comprises react the obtained with an acid diluted in an inert solvent; finally, the composed react obtained with a solution of acid hydrogen and of acid, after or 1996 in the acid and after in the presence of a catalyst, thereby obtaining an ester derivative of the product of formula 1 which, by saponification, followed by neutralization of the resultant mixture, leads to the peptide of formula (1).