NOVEL HYBRID CELLS SECRETING ANTI-IDIOTYPIC ANTIBODIES, NOVEL MONOCLONAL ANTIBODIES SECRETED BY THESE HYBRID CELLS, THEIR PREPARATION AND THEIR APPLICATION

摘要

P HYBRID CELL LINES CAPABLE OF SECRETING ANTI-IDIOTYPIC ANTIBODIES DIRECTED AGAINST ANTI-LIGAND IMMUNOGLOBULIN; THESE CELLULAR LINES OBTAINED BY FUSION ARE SELECTED SUCCESSIVELY ACCORDING TO THE FOLLOWING CUMULATIVE CRITERIA: / P P A. ANTIBODIES THAT ARE SECRETED ARE CAPABLE OF RECOGNIZING THE IDIOTYPIC MONOCLONAL ANTIBODY; / P P B.LES ANTIBODIES THAT ARE SECRETED ARE CAPABLE OF INHIBITING THE FIXATION OF THE LIGAND AND / OR AGONISTS AND / OR ANTAGONISTS OF THE SAID LIGAND; / P P C. THE ANTIBODIES THAT THEY SECURE ARE CAPABLE OF RECOGNIZING CELLS OR COMPONENTS OF CELLS CARRYING OUT THE RECEPTOR DUDIT LIGAND. The invention also relates to a process for the preparation of these cell lines, the new monoclonal antibodies secreted by these hybrid cells, and their use in particular as marker reagents for the ligand receptor or as INGREDIENTS. ACTIVE INGREDIENTS IN THE PREPARATION OF AGONISTIC OR ANTAGONIST DRUGS OF DUDIT LIGAND. / P