New 1-(5-isopropyl-4-(2-(2-methoxyphenyl)piperazinylethoxy)- 2-methylphenoxy)-3-alkylamino-2-propanols, method of preparing them and their therapeutic application

摘要

The present invention relates to new 1-(5-isopropyl-4-(2- [(2-methoxyphenyl)piperazinyl]ethoxy)-2-methylphenoxy)-3-alkylamino- 2-propanols, a method of preparing them and their therapeutic application. The present invention relates to products of formula: IMAGE in which R represents a branched lower alkyl group such as isopropyl or tert-butyl. These new derivatives may be in the form of a free base or of pharmaceutically compatible salts such as their hydrochlorides. They are prepared for example by the reaction between a 1-[4-(haloethoxy)-5-isopropyl-2-methylphenoxy]-3-alkylamino-2-propanol and (2-methoxyphenyl)piperazine in the presence of triethylamine and ethanol. The products which are the subject of the present invention are useful in human and veterinary therapy, in particular in the treatment of high blood pressure.