Synthesis, Crystal Structure and Biological Activity of 1-(4-(4-Ethoxybenzyl)piperazin-1-yl)-2-(2-methylphenoxy)ethanone

摘要

One novel phenoxyacetamide derivative (C22H28N2O3,Mr =368.47) has been synthesized and determined by means of NMR spectroscopy,high resolution mass spectra and single-crystal X-ray diffraction.The single crystal belongs to the monoclinic system,space group Cc with a =14.910(3),b =14.592(3),c =38.683(8) A,β =100.37(3)°,V=8279(3) A3,Z=16,Dc=1.183 g/cm3,F(000) =3168,μ =0.079 mm-1,MoKa radiation (2 =0.71073 A),the final R =0.0508 and wR =0.0666 for 4120 observed reflections with I ＞ 2σ(I).There are four independent molecules in an asymmetric unit cell.The four symmetry-independent molecules have a variety of different conformations indicating considerable conformational freedom.The bioassay results indicated that the title compound displayed effective activities against glutamine-induced neurotoxicity in PC 12 cells and significantly prolonged the survival time of mice subjected to acute cerebral ischemia.