Catalytic oxidation of 3,3-dimethyl-2-hydroxybutyric acid to 2- oxo acid and preparation of 4-amino-6-tert.-butyl-3-thio-1,2,4-triazine- 5(4-H)-one

摘要

Sodium 3,3-dimethyl-2-hydroxybutyrate and ruthenium dioxide hydrate are added to water, the pH rendered alkaline, and sodium hypochlorite is slowly added to produce sodium 3,3-dimethyl-2-oxobutyrate in high yield and purity. The solid catalyst is filtered off and may be re-used while the filtrate can be directly used in further synthesis.