STEREOSELECTIVE REARRANGEMENT AND REDUCTION OF ALPHA-HALOKETONE

摘要

PURPOSE:To obtain an optically active alcohol of particularly high purity, by reacting an alpha-haloketone with an alkylaluminum halide at about ordinary temperature to carry out the rearrangement and reduction stereoselectively at the same time. CONSTITUTION:An alpha-haloketone, e.g. decyl chloride, particularly preferably an optically active compound is reacted with a compound expressed by the formula RAlX2 (R is alkyl; X is halogen), e.g. isobutylaluminum chloride, at =50 deg.C, i.e. 0-50 deg.C, to carry out the rearrangement and reduction stereoselectively at the same time and afford the aimed alcohol of 100% optical purity. USE:An organic compound useful in the field of the so-called fine chemistry, e.g. medicines, agricultural chemicals, etc.