PERCUTANEOUS ABSORPTION OF VALPROIC ACID

摘要

PURPOSE:To well and percutaneously absorb valproic acid useful as an antiepileptic agent by a simple method, by dissolving or suspending valproic acid, ester or nontoxic salt thereof in water to give a drug solution and bringing the resultant drug solution into contact with the skin. CONSTITUTION:Valproic acid (chemical name; 2-propylvaleric acid), ester, preferably ethyl ester or nontoxic salt thereof, preferably Na salt is dissolved or suspended in water to give a drug solution, which is then brought into contact with the skin to percutaneously absorb the valproic acid. The drug solution may be an aqueous gel form. Specifically, the drug solution 2 in encapsulated in a case 7 having one opened side and the case is brought into contact with the skin. The drug solution 2 may be impregnated into an absorption member, e.g. gauze 1, etc., contained in the case 7 or an aqueous gelatinous material of the drug solution may be encapsulated. Spray of the valproic acid ester may be applied to emergency administration and has remarkable usefulness.