NEW MATERIAL:The benzimidazolin-2-one derivative of formula I [R1 is H, halogen, lower alkyl or lower alkoxy; R2 is lower alkyl or aralkyl; Y is (branched) 2-4C alkylene chain; Z is secondary amino] and its acid addition salt. EXAMPLE:1-Benzyloxy-3-(2-diisopropylaminoethyl)benzimidazolin-2-one. USE:A remedy for ulcer having mild central activity and effective in remedying gastric ulcer, duodenal ulcer, etc., caused by stress, etc. PREPARATION:The compound of formula I can be produced by reacting a compound of formula II (most of which are known compounds) with an amine derivative of formula X-Y-Z (X is halogen or acid residue) or its acid addition salt in an inert solvent in the presence of a base.
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机译:新材料:式I [R 1]的苯并咪唑啉-2-酮衍生物为H,卤素,低级烷基或低级烷氧基; R 2为低级烷基或芳烷基; Y为(支链)2-4C亚烷基链; Z是仲氨基]及其酸加成盐。实施例:1-苄氧基-3-(2-二异丙基氨基乙基)苯并咪唑啉-2-一。用途:一种具有中枢活性的溃疡疗法,可有效缓解由压力等引起的胃溃疡,十二指肠溃疡等。制备:式Ⅰ化合物可通过使式Ⅱ化合物反应(大多数是在碱存在下在惰性溶剂中具有式XYZ胺衍生物(X为卤素或酸残基)或其酸加成盐的已知化合物)。
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