首页>
外国专利>
method for preparation of pharmaceutical preparations and methods for preparation of ergolinederivaten.
method for preparation of pharmaceutical preparations and methods for preparation of ergolinederivaten.
展开▼
机译:药物制剂的制备方法和麦角灵碱的制备方法。
展开▼
页面导航
摘要
著录项
相似文献
摘要
1505296 8-Thiomethylergoline derivatives ELI LILLY & CO 3 June 1975 [6 June 1974] 23869/75 Heading C2C Novel compounds of the Formula II wherein R is H, CN, COalk, phenyl or alk; RSP1/SP is H, Cl or Br; alk is C 1-3 alkyl and the dotted line is an optical bond and pharmaceuticallyacceptable acid addition salts thereof, may be prepared by reacting a compound of the Formula III wherein R 2 is methanesulphonyl or p-toluene sulphonyl with an alkali metal salt of a compound RSP3/SP5H, wherein RSP3/SP is CN, COalk, phenyl or alk, optionally followed where RSP3/SP is -COalk by hydrolysis to produce a compound II in which R is H. D - 6 - Methyl - 8 - mesyloxymethylergoline and its 9,10-didehydro derivative are prepared by reacting the corresponding 8-hydroxymethyl compound with methane sulphonyl chloride. Pharmaceutical compositions of the compounds II with the usual excipients are prolactin inhibitors when administered parenterally.
展开▼