poly 4 - aminopyrrool - 2 - carboxamidoderivaten, method for preparation thereof, pharmaceutical preparations containing these derivatives and process for the preparation of the pharmaceutical preparations.

摘要

The invention relates to poly-4-aminopyrrole-2-carboxamido derivatives of the following formula IMAGE wherein, subject to certain provisos, n is zero or an integer of 1 to 4; R is a) -NHR3, wherein R3 is a') -CON(NO)R4, in which R4 is C1-C4 alkyl either unsubstituted or substituted by halogen; or b') -CO(CH2)m-R5, in which R5 is halogen, oxiranyl, methyloxiranyl, aziridinyl, cyclopropyl or the residue of alicyclic, alpha , beta -unsaturated ketone or lactone, and m is zero or an integer of 1 to 4; b IMAGE wherein either R6 and R7 are the same and are each oxiranemethyl, aziridinemethyl, or C2-C4 alkyl 2-substituted by halogen or by a group -OSO2R8, wherein R8 is C1-C4 alkyl or phenyl, or one of R6 and R7 is hydrogen and the other is as defined above; c) -NO2; d) -NH2; or e) -NH-CHO; each group R1 is, independently, hydrogen or C1-C4 alkyl; R2 is a C1-C6 alkyl group terminating with a basic or acidic moiety or with a free or glycosilated hydroxy group; and the pharmaceutically acceptable salts thereof. The scope of the invention includes also pharmaceutical compositions comprising compounds of the above formula and a process for preparing same. The compounds of the invention can be useful antiviral and antineoplastic agents.