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soluble acts to therapy polipeptidici martial derivatives preparation procedure and high iron content and highly their pharmaceutical forms.

机译:可溶物可用于治疗多肽军事衍生物的制备过程,并具有高铁含量和高度药用形式。

摘要

Polypeptide derivatives containing 0.1 to 45% by weight of iron, which are highly soluble at neutral/basic pH and insoluble at acid pH, obtained by a) hydrolysis of succinylated proteins containing iron (FeSP), or b) interaction of succinylated peptides with iron salts (II or III). Said derivatives are very good iron carriers after by oral administration in mammals and show an extremely good tolerability.
机译:含0.1%至45%重量的铁的多肽衍生物,其在中性/碱性pH下高度可溶而在酸性pH下不溶,可通过以下方法获得:a)水解含铁的琥珀酰化蛋白质(FeSP),或b)琥珀酰化肽与铁的相互作用盐(II或III)。所述衍生物在哺乳动物中口服给药后是非常好的铁载体,并且显示出极好的耐受性。

著录项

  • 公开/公告号IT8722276D0

    专利类型

  • 公开/公告日1987-10-14

    原文格式PDF

  • 申请/专利权人 ITALFARMACO S.P.A.;

    申请/专利号IT19870022276

  • 发明设计人 GIANCARLO SPORTOLETTI;PIETRO CREMONESI;

    申请日1987-10-14

  • 分类号A61K;

  • 国家 IT

  • 入库时间 2022-08-22 07:17:55

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