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Process for preparing monoclonal antibodies capable of binding to determinants on seratipicos accessible lipopolysaccharide molecules of gram-negative bacteria.
Process for preparing monoclonal antibodies capable of binding to determinants on seratipicos accessible lipopolysaccharide molecules of gram-negative bacteria.
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机译:制备能够与革兰氏阴性细菌的蛇形菌可及的脂多糖分子上的决定簇结合的单克隆抗体的方法。
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摘要
Transformed human lymphocyte cell lines have been produced which secrete human monoclonal antibodies to serotypic determinants on LPS molecules of gram-negative bacteria. These antibodies have been found to be protective against lethal challenges of the homologous bacteria. Pharmaceutical compositions containing these antibodies and their prophylactic and therapeutic use in the management of gram-negative disease in humans are also disclosed. Human lymphocyte cell lines secreting human monoclonal antibodies specifically reacting with Pseudomonas aeruginosa Fisher immunotypes 1 (C5B7), 2 (6F11), 4 (C5D5), 5 (13C1), 6 (5G2) and 7 (8E7) were deposited at the American Type Culture Collection and given A.T.C.C. Accession Nos. CRL 8753, CRL 8562, CRL 8754, CRL 8796, CRL 8797 and CRL 8795, respectively.
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