Process for the preparation of 170-ethinyl-17b-hydroxy-18-methyl-4,15-estradien-3-one

摘要

A process and novel starting materials for the production of 17 alpha -ethynyl-17 beta -hydroxy-18-methyl-4,15-estradien-3-one of Formula I IMAGE (I) are disclosed. Novel 17-ketone starting materials have the Formula II IMAGE (II) wherein R is an alkyl residue of 1-3 carbon atoms and IMAGE is the grouping IMAGE wherein R' is an acyl group of up to 10 carbon atoms.