Procedure of a New Peptide as a protective Agent against cholera infectious gastroenteritis and - 0.

摘要

Method for preparing a New peptide. Is to set forth the amino acids that constitute the Peptide Chain terminal Valine to a Solid support in the presence of a coupling Agent to obtain a pentadecapeptido D.F (i), which corresponds to the sequence 10 - 24 of the chain to the subunit of the choleric toxin And Presents 5 of 11 amino acids in common with the Chain of the Sub Unit of the thermolabile toxin Escherichia coli LT.The amino acids protected temporarily, with Group F - bentoxicarbonilo (- amylase) groups (benciletes hydroxide resin); Solid support is a clorometilada Resin and the coupling Agent is an equimolecular mixture of diciclohexicarboiidimida and 1 - hydroxy - Benzothiazole, clor URO methylene. Used as a protective Agent against cholera and gastroenteritis.