A process for the preparation of Derivatives of secocantina

摘要

Preparation method of Derivatives of secocantina. To obtain compounds of formula (i), wherein R1 is Hydrogen, halogen, alkoxy or alkyl; R2 and R3 is Hydrogen or a joint Link; R4 and R5 is Hydrogen or an oxo Group; R7 R6 is Hydrogen or alkyl; and choose between different radicals.Through nucleophilic substitution by aminiaco or primary or secondary Amine Compound of formula (ii) which is a group and X - or - ch coo groups where Q and x are outgoing. You can optionally reduce the eventual amido Group, radical transformation and obtain a Salt of pharmacological interest. Application antihipoxica activity and to address the lack of Oxygen to the Brain.