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Thiazolo-pyrimidone deriv. prepn. - by reaction of bis-fluoro-phenyl methyleno piperidino-ethane deriv. with thiazole deriv.
Thiazolo-pyrimidone deriv. prepn. - by reaction of bis-fluoro-phenyl methyleno piperidino-ethane deriv. with thiazole deriv.
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机译:噻唑并嘧啶酮衍生物。准备-通过双氟苯基亚甲基哌啶基乙烷衍生物的反应。与噻唑衍生。
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摘要
6-(2-(4-(bis(4-fluoro phenyl) methyleno) piperidino) ethyl) 7-methyl 5H-thiazolo pyrimidin-5-one, is made by reaction of a cpd. of formula (I) with a cpd. of formula (II), in which Z1 and Z2 are labile gps.. Reaction is carried out in inert organic solvent at from 60 deg.C up to reflux temp. and the prod. is isolated and purified by conventional means.
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