HEMATOLOGICAL PREDICTION OF SEPSIS AND OTHER DISEASE STATES

摘要

ABSTRACT OF THE DISCLOSUREA new diagnostic procedure employing a pre-packaged assay kitto enable the hematological prediction of cancer, sepsis, AIDS and otherpathologic states is described. The kits are composed of sterile plastic testtubes and caps wherein a control tube contains an appropriate amount of physio-logic saline, and an activated tube contains various activators of specificpathways of blood coagulation, e.g. endotoxins dissolved in the same volumeof saline. Upon the addition of a patient's citrated whole blood (CWB) toeach tube, incubation and measurement of recalcification times (RT) are per-formed. A ratio of the control sample RT divided by the activated samples(endotoxin) RT yields a thrombotic index (TI), the values of which are relatedto various disease states. Low numerical values of this index (if endotoxinis the activating material at 10 µg/cc CWB) indicate post surgical patients athigh risk for sepsis (TI µ1.60); values above 1.60 indicate post-surgicalpatients at low risk for sepsis. Normal volunteers have values ranging from1.15 - 1.53 whereas newly diagnosed cancer patients have values of 1.62 to4.39 or higher.