HEMATOLOGICAL PREDICTION OF SEPSIS AND OTHER DISEASE STATES

摘要

A new diagnostic procedure employing a prepacked assay kit to enable the hematological prediction of cancer, sepsis, AIDS and other pathologic states is described. The kits are composed of sterile plastic test tubes and caps wherein a control tube contains an appropriate amount of physiologic saline, and an activated tube contains various activators of specific pathways of blood coagulation, e.g. endotoxins dissolved in the same volume of saline. Upon the addition of a patient's citrated whole blood (CWB) to each tube, incubation and measurement of recalcification times (RT) are performed. A ratio of the control sample RT divided by the activated samples (endotoxin) RT yields a thrombotic index (Ti), the values of which are related to various disease states. Low numerical values of this index (if endotoxin is the activating material at 10µg/cc CWB) indicate post surgical patients at high risk for sepsis (TIµ1.60); values above 1.60 indicate post-surgical patients at low risk for sepsis. Normal volunteers have values ranging from 1.15 - 1.53 whereas newly diagnosed cancer patients have values of 1.62 to 4.39 or higher.