DETECTION, IMAGING AND THERAPY OF RENAL CELL CARCINOMA WITH MONOCLONAL ANTIBODIES IN VIVO

摘要

Three monoclonal antibodies which are highly reactive with human renal cell carcinoma (RCC) were generated by hybridoma techniques and characterized a cell-binding ELISA and immunohistological examination of tumor, normal and fetal tissue sections. The radiolabeled antibodies selectively localized to RCC xenografts and provided high resolution images of the xenographs without the need for background subtraction. The localized, labelled antibodies also produced a regression in the size of the tumors.