Use of dioxopiperidine derivatives in the treatment of anxiety, for the reduction of chronic abnormally high brain levels of serotonin or 5-hydroxy-indoleacetic acid, and in the treatment of bacterial or viral infections

摘要

Phenyl-3-aminoalkyl-4-methyl-2,6-dioxopiperidines of the Formula Iwherein:R₁ represents methoxy, ethoxy or hydroxy,R₂ represents methoxy, ethoxy. hydroxy or hydrogen;each R₃ independently represents methyl or ethyl;R₄ represents hydrogen or methyl;R₅ represents hydrogen or methyl; andn represents 2 or 3,and a pharmacologically acceptable acid addition salt thereof (a) have anxiolytic activity, (b) antagonize the anxiogenic activity of benzodiazepine inverse agonists. (c) reducechronic abnormally high brain levels of serotonin or its metabolite 5-hydroxy-indoleacetic acid and (d) have antibacterial and antiviral activity. These activities are believed to be related to a reduction in serotonin turnover caused by blocking the depolarisation activation of tryptophan hydroxylase. Novel compositions comprise the compounds with a benzodiazepine agonist or benzodiazepine inverse agonist.