Use of dioxopiperidine derivatives in the treatment of anxiety, for the reduction of chronic abnormally high brain levels of serotonin or 5-hydroxy-indoleacetic acid, and in the treatment of bacterial or viral infections

摘要

Phenyl-3-aminoalkyl-4-methyl-2,6-dioxopiperidines of the Formula I …CHEM… wherein:… R1 represents methoxy, ethoxy or hydroxy,… R2 represents methoxy, ethoxy, hydroxy or hydrogen;… each R3 independently represents methyl or ethyl;… R4 represents hydrogen or methyl;… R5 represents hydrogen or methyl; and… n represents 2 or 3,… and a pharmacologically acceptable acid addition salt thereof (a) have anxiolytic activity, (b) antagonize the anxiogenic activity of benzodiazepine inverse agonists, (c) reduce chronic abnormally high brain levels of serotonin or its metabolite 5-hydroxy-indoleacetic acid and (d) have antibacterial and antiviral activity. These activities are believed to be related to a reduction in serotonin turnover caused by blocking the depolarisation activation of tryptophan hydroxylase. Novel compositions comprise the compounds with a benzodiazepine agonist or benzodiazepine inverse agonist.