Method and compositions for the treatment of tumors comprising a calcium channel blocker compound of the dihydropyridine class and a platinum coordination compound

摘要

The invention relates to compositions for the treatment of malignant tumors in a mammal which comprise:(a) a calcium channel blocker compound of the dihydropyridine class selected from the group consisting of wherein R₁ and R₂ are methyl groups, R₃ and R₄ are alkyl or alkyloxyalkylene groups containing l to 8 carbon atoms and R₅ and R₆ are hydrogen or one or two electron withdrawing substituents; and(b) a platinum coordination compound which has antitumor properties in humans wherein the weight ratio of the calcium channel blocker compound to the platinum coordination compound is between l and l000 and l0 to l.;Furthermore, the invention relates to a method for the treatment of malignant tumors in vitro by administering the afore-mentioned compositions.