Methods and compositions for the treatment of tumors with content of a calcium channel blocker - - - compound from the class of the dihydropyridines and on a platinum - coordination compound.

摘要

The invention relates to compositions for the treatment of malignant tumors in a mammal which comprise: (a) a calcium channel blocker compound of the dihydropyridine class selected from the group consisting of CHEM wherein R1 and R2 are methyl groups, R3 and R4 are alkyl or alkyloxyalkylene groups containing l to 8 carbon atoms and R5 and R6 are hydrogen or one or two electron withdrawing substituents; and (b) a platinum coordination compound which has antitumor properties in humans wherein the weight ratio of the calcium channel blocker compound to the platinum coordination compound is between l and l000 and l0 to l. Furthermore, the invention relates to a method for the treatment of malignant tumors in vitro by administering the afore-mentioned compositions.