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Pharmaceutically active phosphino-hydrocarbon-group VIII-metal complexes, antitumor compositions containing these complexes, and a process for preparing said compounds or antitumor compositions
Pharmaceutically active phosphino-hydrocarbon-group VIII-metal complexes, antitumor compositions containing these complexes, and a process for preparing said compounds or antitumor compositions
Novel bis[bis(diphenylphosphino)hydrocarbon] and bis[diphenylphosphino-diphenylarsino)hydrcarbon]-group VIII metal compounds of the formula 1 of the formula sheet, whereinD, = D2 = phosphorus or D, = phosphorus and D2 = arsenic;A = (CH2)2 or cis-CH = CH;X, = X2 (both if present) = halo or nitrato or X, + X = peroxo;Y (if present) = halide, nitrate, perchlorate, triflate or tetrahaloferrate (III);n = 0, 1 or 2;M = Fe(II), Fe(III), Co(II), Rh(I), Rh(III), Ir(I), Ir(III), Ni(II) or Pd(II),showing a tumor cell growth-inhibiting activity, novel pharmaceutical compositions containing said compounds and a method for treating tumor cells, sensitive to said compounds.
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机译：分子式表的式1的新型双[双（二苯基膦基）烃和双[二苯基膦基-二苯基phenyl基]烃] -VIII族金属化合物，其中D ＝ D2 ＝磷或D ＝磷且D2 ＝砷; A ＝（CH 2）2或顺式CH ＝ CH; X ＝ X 2（如果存在的话）＝卤素或硝基或X，+ X ＝过氧; Y（如果存在）=卤化物，硝酸盐，高氯酸盐，三氟甲磺酸盐或四氟铝酸盐（III）; n = 0、1或2; M = Fe（II），Fe（III），Co（II），Rh（I），Rh （III），Ir（I），Ir（III），Ni（II）或Pd（II），抑制肿瘤细胞生长的活性，含有所述化合物的新型药物组合物和对所述化合物敏感的治疗肿瘤细胞的方法。
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