1-Benzyl-2-(N-substituted)-carbamoyl-tetrahydroisoquinolines and method for the preparation thereof

摘要

1-benzyl-2-(N-substituted)-carbamoyl-tetrahydroiso­quinolines of the following formula: in which R₁ and R₂ are independently hydroxyl or methoxyl groups, R₃ is hydrogen or a methoxyl group and R₄ is a methyl or chloroethyl group have an inhibiting effect on beta-adenylatecyclase. The compounds are prepared by reaction of the corresponding 2-unsubstituted tetrahydro­isoquinoline with an isocyanate of formula R₄-N=C=O.