PROCESS FOR EXTRACTING ATRACTYLONE FROM ATRACTYLODES ROOTS

摘要

Atractylone is extd. from atractylode roots. Thus, powd. atractylode roots contg. 13-15% H2O is placed for ext. with Et2O for 1-2days and vaccum-dried. The ether ext. is dissolved in EtOH and saponificated with KOH at 70-80C for 2hr. The soln. is vaccum-evaporated, dissolved in hot water, and extd. with Et20. The ether layer is wahsed with H2O and heat-evaporated to give 8.95g unsaponified matter, which is applied to silica gel G column and eluted with 40% EtOH soln. and later with 50% EtOH soln. The elute is pooled and evaporated in vaccum to give 5.4g atractylone.