METHOD OF PRODUCING CRYSTALLINE SALT OF S-6-FLUORINE-4-UREIDOCHROMAN-4-CARBOXYLIC ACID AND D-(+)-(1-PHENETYL)AMINE OR L-(-)-EPHEDRINE

摘要

Sorbinil is obtained by cyclization of S-6-fluoro-4-ureidochromane-4-carboxylic acid, which is in turn obtained by resolution of racemic 6-fluoro-4-ureidochroman-4-carboxylic acid via diasteromeric salts with either D-(+)-(1-phenethyl)amine or L-(-)-ephedrine.