21-chloro-6alpha; -fluoro-9alpha; -halogen-11beta; -hydroxy-16beta; -methyl-17alpha; -propionyloxy-pregna-1,4-diene-3,20-dione compounds, process for their preparation and pharmaceutical preparations containing these compounds

摘要

9 alpha ,21-Dihalo-11 beta ,17 alpha -dihydroxy-6 alpha -fluoro-16 alpha -methylpregna-1,4-diene -3,20-dione 17-esters of the formula IMAGE in which X1 is chlorine or fluorine, X2 is bromine or chlorine, and Ac is an acyl group derived from a carboxylic acid, are distinguished by high local antiinflammatory activity with a reduced systemic effect, for which reason they can be used in medicine to alleviate and control inflammatory states. They are obtained by conventional replacement of an organic 21-sulphonyloxy group by halogen X2.