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intravenously injectable immunoglobulin with a high antibody titers body with respect to the respiratory syncytial virus, process for its preparation and pharmaceutical preparation which this type
intravenously injectable immunoglobulin with a high antibody titers body with respect to the respiratory syncytial virus, process for its preparation and pharmaceutical preparation which this type
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机译:相对于呼吸道合胞病毒,具有高抗体滴度的静脉注射免疫球蛋白,其制备方法和药物制剂
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摘要
Normal plasma from donors who have not necessarily been vaccinated with a respiratory syncytial virus vaccine can be screened for higher than normal titers of naturally occurring antibody to respiratory syncytial virus (e.g. minimum ELISA titer of at least 1:110,000). Those plasmas with high titers of such antibody can be pooled and fractionated to give hyperimmune globulin. The product may be treated to render it suitable for intravenous injection. Patients with respiratory syncytial virus infection or at risk of such infection, may receive the present product to raise serum antibody titers to respiratory syncytial virus. Resultant product has an ELISA anti-RSV titer of at least about 1:250,000.
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