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Immunotoxins having long-lasting action in vivo, containing the ricin A chain modified on its polysaccharide units
Immunotoxins having long-lasting action in vivo, containing the ricin A chain modified on its polysaccharide units
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机译:体内具有长效作用的免疫毒素,含有在其多糖单元上修饰的蓖麻毒蛋白A链
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摘要
Immunotoxin having long-lasting action in vivo, consisting of a conjugate in which an antibody or antibody fragment is coupled, via a covalent structure containing a disulphide group, to the ricin A chain modified, for the purpose of endowing it with a long-lasting action in vivo, by oxidation of its glycoside units by the action of periodate ions and simultaneous blocking of the oxidation product by formation of a Schiff base with a suitable primary amine.
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