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Molecules with antibody combining sites that bind to hydrolytic transition states
Molecules with antibody combining sites that bind to hydrolytic transition states
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机译:具有结合到水解过渡态的抗体结合位点的分子
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摘要
A phosphonamidate or phosphonate analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester ligand is used to produce antibodies of predetermined specificity. The antibodies include an epitope that binds to and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of the ligand to hydrolyze the ligand at a predetermined site.
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