VIRUS VECTOR FOR DEVELOPING ALPHA 1-AT, MAMMAL CELL TRANSFERRED BY SAID VECTOR, GLUCOSYLATED ALPHA 1-AT, PREPARATION THEREOF AND DRUG CONTAINING ALPHA 1-AT

摘要

A viral expression vector of alpha1-AT or of a variant of alpha1-AT, chosen from: [AA357]alpha1-AT, [AA358]alpha1-AT[AA357,AA358]alpha1-AT and the corresponding variants of the truncated form [delta 1-5]alpha1-AT and [delta 1-5]alpha1-AT, characterised in that it consists of a hybrid virus of the vaccine which contains a DNA sequence coding for the said variant of alpha1-AT inserted into a nonessential part of the virus genome and under the control of an expression sequence which is effective in the vaccine.