ISOLATION OF GENES FOR BIOSYNTHESIS OF POLYKETIDE ANTIBIOTICS

摘要

Novel methods for the isolation and characterization of genes and gene clusters involved in the biosynthesis of polyketide antibiotics. Novel DNA fragments containing such genes as well as vectors containing such genes and bacterial strains containing such vectors are prepared using these methods. The genes and gene clusters isolated by these methods are also employed in methods for the production of a polyketide antibiotic in Streptomyces strains that do not naturally produce the polyketide antibiotic.