PROCESS FOR PREPARING HEXOHYDRO- (1) -BENZO- (PYRANE AND THIOPYRANO) -4,3-C) PYRIDINES

摘要

Disclosed are the compounds of the formula IMAGE (I) wherein X represents oxygen (O) or sulfur (S); ring A is unsubstituted or substituted by one substituent or by two or three identical or different substituents selected from hydroxy, etherified hydroxy, acyloxy, halogen, lower alkyl and trifluoromethyl; or ring A is substituted on adjacent carbon atoms by one lower alkylenedioxy; R represents hydrogen, lower alkyl, aryl-lower alkyl, lower alkenyl, lower alkynyl, aroyl-lower alkyl or aryl-lower alkyl; R1 represents hydrogen, lower alkyl, lower alkylthio-lower alkyl, aryl-lower alkylthio-lower alkyl, (amino, mono- or di-lower alkylamino)-lower alkyl, acylamino-lower alkyl, (hydroxy, acyloxy or etherified hydroxy)-lower alkyl, or cyano-lower alkyl; R2-R7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful as serotonin-2 receptor antagonists in mammals.