Use of substituted alkylidenedithiobis (substituted) phenols for the preparation of pharmaceutical compositions for the inhibition of interleukin-1 release in mammals

摘要

Methods useful for inhibiting the release of Interleukin-1 and for alleviating interleukin-1 mediated conditions, such as IL-1-mediated inflammation, comprising administration of an effective amount of an alkylidenedithiobis(substituted)phenol, preferably, 4,4'-(isopropylidenedithio)bis(2,6-di-tert-butyl) phenol), generically known as probucol.