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soluble silybinderivater, procedure for their preparation and pharmaceutical compositions containing the relations
soluble silybinderivater, procedure for their preparation and pharmaceutical compositions containing the relations
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机译:可溶性水飞蓟宾,其制备方法和含有该关系的药物组合物
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摘要
Novel water-soluble derivatives of silybin of enhanced activity are provided as well as methods of preparing the derivatives and pharmaceutical compositions containing them. The novel derivatives according to the invention have the following general formula (I) CHEM (I) where: a R = H , R min = PO(OH)2 or b R = PO(OH)2, R min = PO(OH)2 The compounds of the invention are useful inter alia in therapy of liver disorders and other applications where an anti-radical effect is required. They have the advantages of high hydrophilicity and are soluble at approximately pH 4, compared to prior art compounds which are water-soluble only at higher pH and enhanced stability.
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机译:提供了具有增强活性的水飞蓟宾的新型水溶性衍生物,以及制备所述衍生物和包含它们的药物组合物的方法。根据本发明的新型衍生物具有以下通式(I)<化学式>(I)其中:a R = H,R min = PO(OH)2或b R = PO(OH)2,R min = PO (OH)2本发明的化合物尤其可用于肝病的治疗和需要抗自由基作用的其他应用。与仅在较高pH下是水溶性的和增强的稳定性的现有技术化合物相比,它们具有高亲水性和在约pH 4下可溶的优点。
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