human monoclonal antibodies and prophylactic ohuman monoclonal antibodies and profulaktiske and therapeutic agents against infrektioese diseases deg therapeutic agents against infrektioese diseasesdr containing same as an active ingredient containing same as active ingredient

摘要

A human monoclonal antibody which reacts with several O antigens of Pseudomonas aeruginosa (esp. with O antigens of type A+F, D+I, E+F, or G+H) is obtd. by culture of a suitable antibody-producing cell line which may be either a virus-transformed cell line (e.g. Epstein-Barr virus-transformed) or a hybridoma derived from human or animal cells, and esp. from normal lymph cells. The antibody is obtd. by culture of one of the following cell lines: MP-5082 (FERM P9745); MP-4095 (FERM-P 9750); MP-5064 (FERM-P 9751); MP-5075 (FERM-P 9752); MP-5104 (FERM-P 9753); MP -5038 (FERM-BP 1596); MP-5035 (FERM-BP 1598) or MP-5046 (FERM -BP 1599).